|Year : 2019 | Volume
| Issue : 1 | Page : 32-34
Salivary duct carcinoma of tongue: A rare entity
Dushyant S Mandlik1, Tulika Dubey2, Shrinal Mankiwala2, Shubhada Kanhere3, Kaustubh D Patel4
1 Consultant, Head Neck, Reconstructive and Robotic Services, Reconstructive and Robotic Services HCG Cancer Centre, Ahmedabad, India
2 Clinical Fellow, Department of Head and Neck, Reconstructive and Robotic Services HCG Cancer Centre, Ahmedabad, India
3 Head, Department of Histopathology, Reconstructive and Robotic Services HCG Cancer Centre, Ahmedabad, India
4 Head and Consultant, Head Neck, Reconstructive and Robotic Services HCG Cancer Centre, Ahmedabad, India
|Date of Web Publication||26-Jul-2019|
Dushyant S Mandlik
Room No. 205, OPD Building, HCG Cancer Centre, Science City, Ahmedabad - 380 060, Gujarat
Source of Support: None, Conflict of Interest: None
Salivary duct carcinomas (SDCs) occur almost exclusively in the major salivary glands. The parotid gland is most commonly affected. SDC of the tongue, arising from a minor salivary gland, is a rare entity. The standard treatment for SDCs is radical surgery in combination with radiotherapy. There is a paucity of cases of this entity in literature, especially affecting the tongue. Hereby, we report a case of an SDC of the anterior tongue.
Keywords: Salivary duct carcinoma, salivary tumour, tongue
|How to cite this article:|
Mandlik DS, Dubey T, Mankiwala S, Kanhere S, Patel KD. Salivary duct carcinoma of tongue: A rare entity. J Head Neck Physicians Surg 2019;7:32-4
|How to cite this URL:|
Mandlik DS, Dubey T, Mankiwala S, Kanhere S, Patel KD. Salivary duct carcinoma of tongue: A rare entity. J Head Neck Physicians Surg [serial online] 2019 [cited 2020 Jan 18];7:32-4. Available from: http://www.jhnps.org/text.asp?2019/7/1/32/263514
| Introduction|| |
Salivary duct carcinoma (SDC) is a rare, aggressive malignancy arising in the ductal epithelium of salivary glands. SDC is common in the parotid gland of elderly people and predominates in males. SDC arising from a minor salivary gland is extremely rare. The term salivary duct carcinoma was coined by Kleinsasser et al. in 1968, after which few studies of this entity have been reported. The standard treatment for SDC is surgery in combination with radiotherapy; however, the prognosis of SDC is poor with frequent distal metastasis. We present a case of SDC of the tongue with bilateral neck nodes.
| Case Report|| |
A 61-year-old male presented with the complaint of multiple neck swellings for 1 week. Clinical examination revealed around 1 cm-sized swelling at the ventral surface of the anterior tongue. There were bilateral, multiple, hard, palpable neck nodes [Figure 1].
His ultrasonogram (USG) of the neck showed bilateral submandibular and jugular nodes. His USG-guided needle cytology from tongue lesion showed moderately differentiated adenocarcinoma. His positron emission tomography (PET)-computed tomography (CT) showed high-grade, fluorodeoxyglucose (FDG)-avid, 24 mm × 10 mm × 18 mm–sized, well-defined exophytic hypodense lesion in the anterior ventral surface of the tongue in the midline. High-grade, FDG-avid, heterogeneously enhancing partly necrotic enlarged multiple neck nodes were seen in bilateral Levels II, III, and IV. USG-guided tru-cut biopsy from left cervical nodes was reported as metastatic moderately differentiated adenocarcinoma [Figure 2] and [Figure 3].
|Figure 3: Color Doppler image with a protruded tongue showing high vascularity|
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He underwent anterior partial glossectomy with bilateral modified radical neck dissection. His final histopathology report showed SDC of the anterolateral tongue (tumor size was 25 mm × 15 mm × 15 mm [depth of invasion]). Immunohistochemical staining with gross cystic disease fluid protein, androgen receptor, and S100 demonstrated focal antibodies with a positive pattern of reaction, which was confirmatory for SDC. Staining with mammaglobin, DOG1, and p63 antibodies was negative. Multiple neck nodes were positive on both sides. As per the American Joint Committee on Cancer 8th Edition, he was staged as pT4aN3bM0 [Figure 4].
|Figure 4: Histopathology image – Cribriform invasive tumor island comprising large cells with a significant nuclear pleomorphism|
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The patient was subjected to postoperative adjuvant radiation (60 Gr over 30 fractions of radiotherapy) after discussion in the multidisciplinary tumor board.
The patient was in regular follow-up with us. At his 2-year follow-up, his clinical examination is oncologically normal. His PET-CT scan at 2-year follow-up is also normal with no locoregional or distant disease.
| Discussion|| |
In 2005, SDC was defined as an independent entity by the World Health Organization, labeling it as “an aggressive adenocarcinoma, which resembles high-grade breast ductal carcinoma and exhibits intraductal and invasive components.” Many terms have been used to report SDC, including cribriform salivary carcinoma of excretory ducts, intraductal carcinoma, and infiltrating SDC, which makes a comprehensive literature search difficult.
Intraoral SDC is a rare malignant neoplasm, accounting for <2% of all malignant minor salivary gland tumors of the oral cavity in a recent series. Although it is difficult to determine the predominant location of SDC in the minor salivary glands because of the limited number of cases, they occur most frequently on the palate followed by buccal mucosa or vestibule, tongue maxilla, mandible, and upper lip.,,,
SDC appears to show an aggressive behavior, with around 25% disease-free survival at 20 months in some series and overall survival of around an average of 56 months.,
Watatani et al. reported intraductal carcinoma originating from the salivary tissue in the tongue, with few infiltrative components and a less aggressive appearance. In contradiction, Suzuki et al. reported a similar case of SDC of the mobile portion of the tongue where the histological findings were compatible with an aggressive neoplasm with a poor prognosis. Advanced nodal disease, lymphovascular invasion, and extracapsular spread have a detrimental survival impact. Aggressive surgical treatment with adjuvant radiation remains cornerstone management as they are locally aggressive with more than 50% regional metastasis.,
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
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Conflicts of interest
There are no conflicts of interest.
This material has never been published and is not currently under evaluation in any other peer reviewed publication.
The permission was taken from Institutional Ethics Committee prior to starting the project. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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[Figure 1], [Figure 2], [Figure 3], [Figure 4]